Papers

Selected papers on DNA resonance and consciousness.

• 1.Imperfection as the Foundation of Life: Imprinting of DNA Sequence on Water (2026)
  Savelev I.V., Rempel M.M., Polesskaya O.O., Miller R.A., Myakishev-Rempel M. — Studies in Rhythm Engineering: Information Fields Theory and Applications, Springer Nature Singapore, pp. 163-219
  Water is not a passive background in the cell - it forms structured layers around large molecules like DNA. This chapter presents a detailed model of how DNA and its surrounding water interact inside the nucleus, proposing that the water continuously reorganizes in response to the sequence it surrounds, so that a DNA sequence can imprint its pattern onto nearby water through a stepwise shifting of water layers. A key consequence is that identical or similar repetitive elements - especially transposons - would tend to stick together through a water-mediated, sequence-specific attraction, recognizing one another partly through the structure they impose on the water between them. Building on the theme that imperfection is the foundation of life, the authors argue that the slightly unstable, ever-shifting nature of these water structures is exactly what makes such information transfer possible, and propose it as a concrete, testable mechanism by which sequence shapes genome organization.
• 2.Patterns of Transposable Element Distribution around Chromatin Ligation Points Revealed by Micro-C Data Analysis (2025)
  Vikhorev A.V., Rempel M.M., Polesskaya O.O., Savelev I.V., Vetcher A.A., Myakishev-Rempel M. — The Open Bioinformatics Journal
  Transposable elements - jumping genes - are repetitive sequences that make up a large fraction of the human genome. This study examines where these elements sit relative to the points where chromatin fibers touch one another inside the nucleus, using high-resolution Micro-C data that maps the genome's three-dimensional contacts. By analyzing how different families of transposable elements are distributed around these contact points, the authors look for non-random patterns - signs that certain repeats are enriched or depleted near where the genome folds back on itself. Such patterns would suggest that transposons help organize, or are organized by, the genome's spatial architecture. Part of a larger program connecting repetitive DNA, genome folding, and the idea that similar sequences preferentially associate, the paper provides bioinformatic evidence relevant to how and why the genome adopts its particular three-dimensional shape.
• 3.Imperfection as the Foundation of Life: The Role of DNA in Reality Rendering (2026)
  Myakishev-Rempel M. — Studies in Rhythm Engineering: Information Fields Theory and Applications, Springer Nature Singapore
  This chapter develops the view that DNA acts as an interface between the physical body and a larger field of consciousness. Its central theme - imperfection as the foundation of life - argues that the constant, slightly disorderly reorganization of chromatin is not a flaw but a feature that makes living matter sensitive to subtle influences. DNA's special physical properties, including its roughly 2-nanometer diameter and perpetual structural shifting, are proposed to let it sit at the boundary between the quantum and classical worlds, where it could exchange information with subtle quantum fields - an exchange the author links to what we experience as consciousness, or reality rendering. The chapter also revisits the hypothesis that DNA imprints its sequence onto surrounding water, weaving together molecular biology, physics, and the philosophy of mind to make consciousness a subject for physical hypotheses rather than philosophy alone.
• 4.Homological Coupling of Chromatin Fibers (2025)
  Myakishev-Rempel M. — Preprint (Preprints.org / MDPI)
  Inside the cell nucleus, the long thread of DNA, packaged as chromatin, folds so that distant parts of the genome touch one another. This study asks whether the DNA sequences at such contact points are more similar to each other than chance would predict. Using long-read chromatin conformation capture data - 12 million PacBio reads from a human cell line - the authors identified 6,055 accurately mapped contact points, developed a method to distinguish genuine contacts from laboratory artifacts, and compared the sequence similarity of real contacting pairs against shuffled controls. They found roughly an 8-fold enrichment of sequence similarity at genuine contact points. This supports their central proposal, homological coupling: that chromatin fibers preferentially pair where their sequences match - sequence-guided pairing that fits the broader theory that DNA recognizes and associates with similar sequences, with implications for how the genome organizes in three dimensions.
• 5.Xenogenetics Research Proposal (XG1) (2024)
  Rempel M. — Research proposal, DNA Resonance Research Foundation
  This is a research proposal rather than a peer-reviewed study. It outlines a speculative program, Xenogenetics (XG1), that proposes using modern population-genetics data to test ideas drawn from the ancient-alien hypothesis - the notion that outside genetic influences may have shaped human evolution. Its premise is that the recent explosion of sequenced and genotyped human genomes from many populations gives researchers an unprecedented ability to trace migration, ancestry, and the timing of genetic changes, and that these tools could be turned toward unconventional questions about the origins of distinct human population features. It should be read as an exploratory, hypothesis-generating statement of questions and proposed methods - not a report of confirmed results - included here for completeness and transparency.
• 6.The Avoidance of Purine Stretches by Cancer Mutations (2024)
  Vikhorev A.V., Savelev I.V., Polesskaya O.O., Rempel M.M., Miller R.A., Vetcher A.A., Myakishev-Rempel M. — Int. J. Mol. Sci.
  DNA is written in four letters, two of which - A and G - are purines. When many purines line up in a row on the same strand, the double helix can adopt unusual physical forms and behaves differently from ordinary DNA. This study asks whether the mutations that drive cancer treat these purine stretches in a special way. Analyzing large datasets of cancer mutations, the authors find a striking pattern: cancer mutations tend to avoid long purine stretches, which are mutated less often than chance would predict. That avoidance suggests the stretches are protected, functionally important, or physically resistant to the processes that introduce cancer mutations. The finding matters because it hints that the physical structure of DNA - not just its letter-by-letter code - shapes where cancer-causing changes occur, offering a new, data-grounded clue for why certain regions of the genome are more stable than others.
• 7.How the Biofield is Created by DNA Resonance (2022)
  Savelev I.V., Miller R.A., Myakishev-Rempel M. — Studies in Rhythm Engineering: Rhythmic Advantages in Big Data and Machine Learning, Springer Nature Singapore, pp. 161-199
  Many traditions and some scientific theories describe a biofield - an organizing field around living things that helps coordinate their structure and function. This chapter asks a concrete question: could such a field be generated by DNA itself, through the electromagnetic resonance of its sequences? The authors develop the idea that the genome, with its enormous number of repeated sequences, acts as a collection of resonators that send and receive electromagnetic signals, whose combined activity could produce a coherent field around cells and tissues - a physical basis for what has loosely been called the biofield, and a way cells might coordinate over distances larger than chemistry alone easily explains. Bringing together physics, molecular biology, and the theme of biological rhythms, the chapter frames the biofield not as something mystical but as a testable consequence of DNA's physical properties.
• 8.How Schrödinger's Mice Weave Consciousness (2022)
  Myakishev-Rempel M., Savelev I.V. — Studies in Rhythm Engineering: Rhythmic Advantages in Big Data and Machine Learning, Springer Nature Singapore, pp. 201-224
  This chapter takes on one of the hardest questions in science - how physical matter could give rise to conscious experience - through the lens of quantum physics and DNA. Borrowing Schrodinger's famous thought experiment, it asks how living systems might weave consciousness from underlying quantum processes. The authors propose that DNA, because of its unique molecular structure and constant reorganization inside the nucleus, is well placed to serve as an interface between the classical biological world and subtle quantum-level phenomena, and that the brain's richly rhythmic activity combined with quantum effects at the molecular scale could provide the conditions in which conscious experience arises. As a theoretical chapter it does not claim to settle the question; it lays out the hypothesis that consciousness emerges from the interplay of quantum mechanics, molecular biology, and the self-organizing behavior of DNA, inviting us to think about mind and matter together.
• 9.Evidence for DNA Resonance Signaling via Longitudinal Hydrogen Bonds (2020)
  Savelev I., Myakishev-Rempel M. — Progress in Biophysics and Molecular Biology
  The idea of a morphogenic field suggests that the chemical signals cells exchange are supplemented by electromagnetic signals that help guide the shape of tissues, organs, and the whole body. The theory of DNA resonance proposes that this field is generated by genomic DNA acting as a sequence-specific sender and receiver of electromagnetic signals. This paper looks for concrete physical evidence of how such signaling could work, focusing on the hydrogen bonds that run along the length of the DNA molecule. The authors argue that these longitudinal hydrogen bonds could support the charge or energy movement that resonance signaling would require, and assemble evidence pointing in that direction. By proposing a specific molecular mechanism, the paper turns a broad theory into something more concrete and checkable - part of a larger effort to give the morphogenic-field and DNA-resonance ideas a footing in measurable physics and chemistry and to suggest experiments that could confirm or rule it out.
• 10.Possible Traces of Resonance Signaling in the Genome (2019)
  Savelev I., Myakishev-Rempel M. — Progress in Biophysics and Molecular Biology
  Theories that DNA sequences can resonate - communicating through physical vibration rather than only chemistry - have circulated for over forty years, yet hard published evidence has been scarce. This paper takes a data-driven approach: if resonance signaling is real and sustained, a genome should contain an unusually large number of matching, oscillating sequences that could act as resonators. The authors reason that the genome's repeated sequences, which come in many sizes and vast numbers, are the natural candidates, and argue that two stretches need not be identical to resonate together, which widens the pool of possible partners. They then search the genome for statistical traces - arrangements expected if resonance signaling were occurring - moving the idea from speculation toward testable observation by looking for its fingerprints directly in genomic data, and inviting further analysis of whether the genome is organized to support resonance-based communication.
• 11.On the Existence of the DNA Resonance Code and Its Possible Mechanistic Connection to the Neural Code (2019)
  Savelyev I.V., Zyryanova N.V., Polesskaya O.O., Myakishev-Rempel M. — NeuroQuantology
  For decades a provocative idea has circulated at the edge of biology: that DNA does not only store information as a chemical code but might also behave physically, vibrating or resonating at particular frequencies. This paper asks whether such a DNA resonance code could really exist, and whether it might connect to the way nerve cells signal in the brain. The authors review the physics and chemistry that could let specific DNA sequences act as resonators and propose that the genome's vast collection of repeated sequences is exactly what such a system would need - many copies of the same note that could reinforce one another. They then explore a bold parallel: that the rhythms and codes used by neurons might share a common logic with this proposed DNA resonance. Rather than proving the effect, the paper defines what a DNA resonance code would be, why repeated sequences are good candidates to carry it, and how it might tie into the neural code, setting out a framework and concrete predictions for those willing to test it.
• 12.The Role of Alu-derived RNAs in Alzheimer's and Other Neurodegenerative Conditions (2018)
  Polesskaya O., Kananykhina E., Roy-Engel A.M., Nazarenko O., Kulemzina I., Baranova A., Vassetsky Y., Myakishev-Rempel M. — Medical Hypotheses
  Scattered more than a million times across human DNA is a short, repetitive sequence called the Alu element - one of the most successful jumping genes in our genome. Most of the time these copies sit quietly, but the cell still occasionally transcribes them into small RNA molecules, and that activity rises with age and cellular stress. This paper proposes that an abnormal build-up of Alu-derived RNAs is an under-appreciated contributor to Alzheimer's disease and other neurodegenerative conditions. The authors gather evidence that, when normal control over these repeats breaks down, the resulting RNAs can interfere with the machinery that processes other RNAs, disturb protein production, and add to the cellular damage seen in aging brains. Rather than reporting a single experiment, the article assembles findings from genetics, RNA biology, and neurology into a coherent, testable hypothesis, pointing to these ancient repeats - and the cell's ability to keep them in check - as a possible target for understanding and treating neurodegeneration.
• 13.On Possible Role of DNA Electrodynamics in Chromatin Regulation (2017)
  Polesskaya O., Guschin V., Kondratev N., Garanina I., Nazarenko O., Zyryanova N., et al., Myakishev-Rempel M. — Progress in Biophysics and Molecular Biology
  For decades biologists have tried to predict when a gene switches on or off by reading the DNA letters around it - promoters, transcription-factor binding sites, regulatory elements - yet even the best computational tools still fail to predict gene activity reliably. This paper argues that the missing piece may not be more of the same kind of information but a different physical property of DNA altogether: its behavior as an electrical and electromagnetic device. The authors review evidence that the DNA double helix can conduct electricity along its length and respond to electromagnetic fields, somewhat like a tiny antenna or resonator, and propose that particular sequences and structures could act as electromagnetic resonators and oscillators tuned to specific frequencies. If so, the cell could use these electromagnetic properties as an extra layer of regulation beyond the chemical code - a hypothesis the paper develops and connects to testable physics.